孙慧 博士,教授,硕士生导师
环境科学与工程学院
广州大学
广州大学城外环西路230号,510006
Tel.:020-39366943
E-mail:esesunhui@gzhu.edu.cn
教育背景
2006年毕业于香港大学化学系,获博士学位
2002年毕业于南开大学化学系,获硕士学位
1994年毕业于武汉大学环境科学系,获学士学位
工作经历
1. 2010/10-至今, 广州大学,环境科学与工程学院,教授
2. 2006/08-2010/09, 香港大学,化学系,博士后,
研究方向
环境功能材料以及原位检测技术研究。
科研项目
曾主持国家自然科学基金3项,教育部重点科学技术1项,广东省自然科学基金1项,广州市科技计划项目1项,香港大学博士后基金1项。
1.光子晶体-离子印迹共价有机骨架材料在放射性核素等重金属富集分离和检测中的应用研究。(国家自然科学基金项目21876033,2019-2022,主持)
2.基于离子印迹与识别的重金属离子荧光光纤传感器的研究(国家自然科学基金项目21477026,2015-2018,主持)
3.基于分子印迹微流控CE系统的空气羰基化合物分析的研究(国家自然科学基金项目21107018,2012-2014,主持)
4.空气中微量气、固态醛酮化合物测定的芯片技术研究(教育部科学技术研究重点项目212129,2012-2015,主持)
5.大气PM2.5中羰基化合物的分子识别及微流控芯片监测系统研究(广东省自然科学基金项目2014A030313525,2015-2017,主持)
6.雾霾中醛酮类污染物的快速检测系统研究(广州市科技计划项目201504291741356,2016-2019,主持)
7.基于分子印迹和微流控技术的压电传感器在环境和临床中的应用研究(香港大学博士后基金项目200807176235,2009-2010,主持)
8.抗生素分子印迹光子晶体光纤传感器阵列的设计、构建及其应用研究(国家自然科学基金项目21677053,2017-2020,参与)
9.基于离子识别和光纤传导的重金属离子荧光传感器的关键敏感元件研究(广东省普通高校特色创新项目,2015-2017,参与)
10.城市湖泊水体微表层种短链氯化石蜡的富集特征及其影响因素研究(广东省自然科 学基金项目2016A030310264,2016-2019,参与)
11.量子点协同激光诱导荧光测定蛋白和肽生物标记物的微流控芯片毛细管电泳研究(香港大学基础研究种子基金201111159206,2012-2014,参与)
12.基于微流控芯片-毛细管电泳技术以及非指数富集核酸适配体筛选技术的压电石英晶体传感器在病原性蛋白标记物中测定中的应用研究(香港综合研究基金HKU702210P,2010-2013,参与)
13.微电极-微流控芯片毛细管电泳装置测定未标记核酸(香港大学基础研究种子基金201011159211,2011-2013,参与)
14.基于微流控芯片-毛细管电泳技术以及非指数富集核酸适配体筛选技术的压电石英晶体传感器在测定病原性蛋白标记物中的应用研究(香港大学基础研究种子基金,200911159175,2010-2012,参与)
15.基于微流控芯片-毛细管电泳通道内微电极进行原位测定具有重要生物医学意义的分子(香港大学基础研究种子基金200811159134,2009-2011,参与)
16.压电-DNA生物传感器系统在细菌测定中的应用研究(香港大学应用研究种子基金200802160019,2008-2009,参与)
17.基于分子印迹识别和石英微天平传感器的“电子舌”技术研究(香港特别行政区创新科技基金ITS/108/06,2006- 2007,参与)
发表论文、专著、专利
在Biosens. Bioelectro., Anal. Chim. Acta, J. Chromatogr. A,Analyst等杂志上发表学术论文40余篇,曾参与“Encyclopedia of Sensors”及“Microfluidic Chip- Capillary Electrophoresis (MC-CE) Devices ”著作编写,获得美国专利1项及中国专利4项。
代表性论文:
1. Qingda Huang, Caihua Lv, Xiaolin Yuan, Miao He, Jiaping Lai, Hui Sun*, A novel fluorescent optical fiber sensor for highly selective detection of antibiotic ciprofloxacin based on replaceable molecularly imprinted nanoparticles composite hydrogel detector. Sensors and Actuators B: Chemical 2021, 328, 129000
2. Siyang Fang, Yangyang Liu, Jiahua He, Liuqing Zhang, Zhengxi Liyin, Xiaoyi Wu, Hui Sun*, Jiaping Lai, Determination of aldehydes in water samples by coupling magnetism-reinforced molecular imprinting monolith microextraction and non-aqueous capillary electrophoresis. Journal of Chromatography A, 2020, 1632, (22) 461602
3. Yi Zhang, Zhenkai Jin, Qingsong Zeng, Yanmei, Huang, Hang Gu, Shili Chen, Jiahua He, Yangyang Liu, Hui Sun*, Jiaping Lai, Field Visual Inspection of Illegal Additive in Wine Based on Functional Photonic Crystal Sensor, Microchimia Acta, 2019,186 (11).
4. Yunling Li, Hui Sun*, Jiaping Lai, Xiangyang Chang, Ping Zhang, Shili Chen Determination of carbonyl pollutants adsorbed on ambient particulate matter of type PM2.5 by using magnetic molecularly imprinted microspheres for sample pretreatment and capillary electrophoresis for separation and quantitation, Microchimica Acta 2018, 185 (2):122-134.
5. Mengxia Huang, Jiaping Lai, Hui Sun*Weizhen Wu. A simple, highly selective and ultra-sensitive "off-on-off" fluorescent chemosensor for successive detection of aluminum ion and phosphate in water samples. Microchemical journal, 2019,151.
6. Shili Chen, Hui Sun*, Zhenjian Huang, Siyang Fang, Jiahua He, Yangyang Liu, Jiaping Lai, Yi Zhang, Zhenkai Jin, Visual detection of anesthetics in fish based on inverse opal photonic crystal sensor, RSC Advances, 2019, 9 (29): 16831 - 16838.
7. Mengxia Huang, Caihua Lv, Qingda Huang, Jiaping Lai, Hui Sun* A novel and fast responsive turn-on fluorescent probe for the highly selective detection of Cd2+ based on photo-induced electron transfer. RSC Advances 2019,9 (62): 36011-36019.
8. Weizhen Wu, Mengxia Huang, Qingda Huang, Caihua Lv, Jiaping Lai, Hui Sun*, Molecularly Imprinted Photonic Hydrogelsfor Visual Detection of Methylanthranilate in Wine. Chin. J. Anal. Chem., 2019, 47 (9) : 1330-1336.
9. Siyang Fang, Shili Chen, Jiahua He, Hao Wang, Lisi Shen, Yangyang Liu, Hui Sun*, Jiaping Lai*, Determination of carbonyls in ambient PM2.5 by coupling dummy template imprinting technology and high performance liquid chromatography. Chin. J. Chromatography, 2019.37 (6): 634-643
10. Shili Chen ; Zhenjian Huang; Siyang Fang; Jiahua He; Yangyang Liu; Jiaping Lai , Hui Sun*, Molecular Imprinted Photonic Crystal Sensor For The Rapid and Visual Detection of Benzocaine In Fish, Key Engineering Materials. (ISSN: 1662-9795), 2019,803,129-133.
11. Hui Sun, Jiaping Lai, Dongsheng Lin, Xuexia Huang, Yunling Li, A novel fluorescent multi- functional monomer for preparation of silver ion-imprinted fluorescent on-off chemosensor. Sens. Actuat. B, 2016, 224: 485-491.
12. Yanhui He, Jiaping Lai, Hui Sun*, Zhiming Chen, Sheng Lan. A fast, sensitive and stable fluorescent fiber-optic chemosensor for quantitative detection of Fe3+ in real water and HepG2 living cells. Sens. Actuat. B, 2016, 225:405-412.
13. Fashuo Shan, Jiaping Lai, Hui Sun*, Ping Zhang, Chong Luo, Yanhui He, Huanran Feng. A facile, fast responsive and highly selective mercury(II) probe characterized by the fluorescence quenching of 2,9-dimethyl-1,10-phenanthroline and two new metal-organic frameworks. RSC Advances, 2016, 6, 66215-66223.
14. Hui Sun, Jiaping Lai, Fang Chen, Derong Zhu. Molecularly imprinted microspheres synthesized by a simple, fast and universal suspension polymerization for selective extraction of topical anesthetics benzocaine in human serum and fish tissues. Anal. Bioanal. Chem., 2015, 407: 1745-1752.
15. Jiaping Lai, Yue Zuo, Hui Sun*, Ying Yu. Hydrophilic molecularly imprinted microspheres functionalized with amino and carboxyl groups for highly selective recognition of human hemoglobin in aqueous solution, RSC Advances,2015,5(63): 51392-51398.
16. Hui Sun, Jiaping Lai*, Yingsing Fung, Simultaneous determination of gaseous and particulate ambient carbonyls by coupling micellar electrokinetic capillary chromatography with molecular imprinting solid-phase extraction. J. Chromatogr. A, 2014, 1358: 303-308.
17. Jiaping Lai, Fang Chen, Hui Sun*, Li Fan, Yue Zuo. Molecularly imprinted microspheres for anti-cancer drug aminoglutethimide: synthesis, characteri- zation and solid-phase extraction application in human urine sample. J. Sep. Sci., 2014, 37:1170-1176.
18. Dongsheng Lin, Jiaping Lai, Hui Sun*, Zhou Yang, Yue Zuo. A turn-on fluorescein spirolactam derivative as a high selective fluorescence probe for detection of silver ion (I) in water. Anal. Methods, 2014, 6: 1517-1522.
19. Jiaping Lai, Li Xie, Hui Sun*, Fang Chen. Synthesis and evaluation of molecularly imprinted polymeric microspheres for highly selective extraction of an anti-AIDS drug emtricitabine. Anal. Bioanal. Chem., 2013,405: 4269-4275.
20. Derong Zhu, Hui Sun*, Hongju Liu, Minghua He, Comparison of Determination Methods for Phthalates by Liquid-Phase Microextraction Coupled Gas Chromatograph-Mass spectrometry. Chin. J. Anal. Chem., 2013,41 (10):1582-1586.
21. Hui Sun, Kwokman Lau, Yingsing Fung*, A new capillary electrophoreSis buffer for determining organic and inorganic anions in electroplating bath with surfactant additives, J. Chromatogr. A,2010, 1217: 3244-3250.
22. Hui Sun, Zhou Nie, Yingsing Fung*. Determination of free bilirubin and its binding capacity by HSA using a microfluidic chip-capillary electrophoresis device with a multi-segment circular-ferro fluid-driven micromixing injection. Electrophoresis, 2010, 31(18): 3061-3069.
23. Hui Sun, Yingsing Fung. DNA biosensor based on quartz crystal microbalance and polymerase chain reaction for detecting E. Coli. in environmental water. Biosens. Bioelectron., 2009, 24:1405-1411.
24. Hui Sun, Zhihong Mo, Jacqueline Tszshan.Choy,Derong Zhu, Yingsing Fung*. Development of piezoelectric quartz crystal sensor array for sensing taste-causing compounds in food. Sens. Actuat. B, 2008, 131: 148-158.
25. Hui Sun, Kingyee Chan, Yingsing Fung*. Determination of gaseous and particulate carbonyls in air by gradient-elution micellar electrokinetic capillary chromatography. Electrophoresis, 2008, 29: 3971-3979.
26. Hui Sun, Yingsing Fung*, Flow analysis coupled with PQC/DNA biosensor for assay of E. coli based on detecting DNA products from PCR amplification. Biosens. Bioelectron., 2006, 22: 506-512.
27. Hui Sun, Yingsing Fung*. Piezoelectric quartz crystal sensor for rapid analysis of piriicarb residues using molecularly imprinted polymers as recognition elements. Anal. Chim. Acta, 2006, 576: 67-76. (SCI影响因子 5.256)
28. Hui Sun, Youyu Zhang, Shihui Si, Derong Zhu, Yingsing Fung*. Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water. Sens. Actuat. B-Chem. 2005, 108: 925-932.
29. Hui Sun, Shihui Si, Youyu Zhang, Derong Zhu, Yingsing Fung*. Piezoelectric quartz crystal (PQC) with photochemically deposited nano-sized Ag particles for determining cyanide at trace levels in water. Chem. Sens. 2004, 20: 500-501.
30. Hui Sun, Xiangchao Dong, Xianyu Lv, Haibo Wang, Jianfang, Han, Separation and Determination of Fluoroquinolones with a Molecularly Imprinted Polymer. Chin. J. Chromatography, 2003,21 (3): 233- 238.
专著:
1. Hui Sun, Yingsing Fung, (Chapter 6) sample cleanup and analyte enrichment -integrating MIP/SPE with ME/MC-CE device to enhance sample cleanup and multi-dimension analyte enrichment for hourly determination of atmospheric carbonyl compounds, Microfluidic Chip-Capillary Electrophoresis (MC-CE) Devices -Integrating techniques to achieve intended applications, CRC press, 2015
2. Yingsing Fung, Youyu Zhang, Shihui Si, Hui Sun and Shouzhuo Yao, DNA Piezoelectric Quartz Crystal Biosensor, Encyclopedia of Sensors, American Scientific Publishers, CA, USA. 2006
专利:
1. Yingsing Fung, Hui Sun, Zhihong Mo, Derong Zhu, Jacqueline Tszshan Choy, Yinyee Lee, Electronic Tongue Sensor, 2011.9, US Patent, 8,004,152。
2. 赖家平,左悦,林东升,孙慧,何燕惠,一种荧光多功能单体及其合成方法与应用,发明专利,2015.4.30,中国,ZL 201510217322.6。
3. 冯应升;孙慧; 莫志宏; 朱德荣;蔡紫珊; 李贤意. 电子舌传感器,2013.4,中国, CN101836107A。
4. 陈永亨;张平; 陈绮洁; 姚焱;吴颖娟; 黄雪夏; 李祥平;孙慧. 一种以铅锌矿冶炼废水为原料制备碘化亚铊的方法,2014, 中国, CN103818947A。
5. 孙慧, 李韵灵, 常向阳 2,4-二硝基苯胺磁性分子印迹复合材料的制备方法和应用, 发明专利,中国,201610928664.3。
研究生及本科生培养
现指导在读硕士研究生8名;多次获本科课堂教学优秀”一等奖”及“二等奖”;2017年被评为“最受学生欢迎的老师”。